Nausea

Key Messages

  • Palliative diagnosis that frequently cause nausea and / or vomiting include intra-abdominal or gastrointestinal malignancies.
  • There are no widely accepted assessment tools for nausea and vomiting in palliative care.
  • Clinical practice guidelines for palliative management of malignant bowel obstruction are available. [1]
  • Parenteral hydration is sometimes indicated to correct nausea, whereas regular mouth care is the treatment of choice for a dry mouth.
  • The evidence base to support prescribing of antiemetics in palliative care is not well developed and there are no clear recommendations on which medication to use. Evidence supports the use of the antiemetics metoclopramide and 5HT3 antagonists in advanced cancer.
  • In the case of opioid-related nausea there is limited evidence to support the practice of opioid rotation or switching.
  • It is likely that steroids hasten the resolution of bowel obstruction, [2] although this conclusion is based on very small studies and the effect size was small.
  • The option of rectal or gastroduodenal stenting in malignant obstruction appears to offer good palliation in selected patients. [3,4]
  • Surgery for bowel obstruction should not be undertaken routinely in patients with poor prognostic criteria, such as intra-abdominal carcinomatosis, poor performance status, and massive ascites, older age.

  

  

  

PubMed Searches

Evidence Summary

Definition and Prevalence

Nausea can either be acute, or chronic, and is not always associated with vomiting. In many cases it is possible to identify a cause, although in the palliative care population nausea is frequently multifactorial.

Palliative diagnosis that frequently cause nausea and / or vomiting include intra-abdominal or gastrointestinal malignancies - especially those which result in bowel obstruction; central nervous system malignancy - which may cause raised intracranial pressure, cerebellar or vestibular symptoms; and HIV AIDS.

Other factors that contribute to nausea and / or vomiting that should be considered, and treated where possible, include:

  • Metabolic imbalance, including hypercalcemia, uraemia, liver failure
  • Sepsis (including urinary tract and respiratory tract infection)
  • Conditions affecting gastrointestinal motility, including constipation, previous surgery, gastroparesis, or autonomic failure
  • Reflux or peptic ulcer disease
  • Medication and treatment side effects, including opioids and other drugs, chemotherapy, and radiotherapy
  • Anxiety and depression, anticipatory nausea
  • Inappropriate presentation of food.

Assessment

There are no widely accepted assessment tools for nausea and vomiting in palliative care, particularly for research. Nausea must be self-assessed by patients, whereas vomiting can be monitored objectively. Nausea is routinely assessed in Australian palliative care services using Symptom Assessment Scores (SAS) which is part of the PCOC dataset.

Treatment

A systematic review has identified evidence to support the use of metoclopramide and 5HT3 antagonists in advanced cancer. [5] Other antiemetics are frequently used in palliative care, but at present lack a strong evidence base. The choice of an antiemetic for nausea may be either empirical, or aetiological - related to the likely main mechanism of nausea and / or vomiting. There is no evidence to support one approach over the other, based on a systematic review of randomised controlled trials. [5]

Nausea is a common side effect of opioid use and much of the research generated on opioid-induced nausea and vomiting comes from an acute and post-operative clinical setting. A recent systematic review of nausea and vomiting associated with opioids identified limited evidence to support the practice of opioid rotation or switching. [6] There are guidelines recommending clinical practice for treating nausea in cancer. [7] There is limited specific evidence for antiemetic choice in older people or paediatrics.

Use of antiemetics is examined in more detail in a separate section as is bowel obstruction related to gastrointestinal malignancy.

More on this topic:

Antiemetics
Malignant Bowel obstruction

Evidence Gap

  • There are no widely accepted assessment tools for nausea and vomiting in palliative care.
  • Despite widespread use in palliative care, there is currently no high level evidence supporting the use of haloperidol as an antiemetic. [8]
  • A recent meta-analysis of cannabis based medications did not find these medications superior to conventional anti-emetics. [9]
  • A multisite randomised controlled trial studying antiemetics in palliative care is underway in Australia. It will firstly test whether prescribing according to clinical guidelines based on the presumed mechanism of nausea is effective, and secondly for patients with refractory nausea, will compare methotrimeprazine (levomepromazine) with either ondansetron or best supportive care using other antiemetics.
  • The role of various complimentary therapies continue to be investigated. [10]

 

  1. Ripamonti C, Twycross R, Baines M, Bozzetti F, Capris S, De Conno F, et al. Clinical-practice recommendations for the management of bowel obstruction in patients with end-stage cancer. Supportive Care Cancer. 2001 Jun;9(4):223-33.
  2. Feuer DJ, Broadley KE. Corticosteroids for the resolution of malignant bowel obstruction in advanced gynaecological and gastrointestinal cancer. Cochrane Database Syst Rev. 2000;(2):CD001219.
  3. Hosono S, Ohtani H, Arimoto Y, Kanamiya Y. Endoscopic stenting versus surgical gastroenterostomy  for palliation of malignant gastroduodenal obstruction: a meta-analysis. J Gastroenterol. 2007 Apr;42(4):283-90. Epub 2007 Apr 26.
  4. Mintziras I, Miligkos M, Wächter S, Manoharan J, Bartsch DK. Palliative surgical bypass is superior to palliative endoscopic stenting in patients with malignant gastric outlet obstruction: systematic review and meta-analysis. Surg Endosc. 2019 Oct;33(10):3153-3164. doi: 10.1007/s00464-019-06955-z. Epub 2019 Jul 22.
  5. Glare P, Pereira G, Kristjanson LJ, Stockler M, Tattersall M. Systematic review of the efficacy of antiemetics in the treatment of nausea in patients with far-advanced cancer. Support Care Cancer. 2004 Jun;12(6):432-40. Epub 2004 Apr 24.
  6. Sande TA, Laird BJA, Fallon MT. The Management of Opioid-Induced Nausea and Vomiting in Patients with Cancer: A Systematic Review. J Palliat Med. 2019 Jan;22(1):90-97. doi: 10.1089/jpm.2018.0260. Epub 2018 Sep 21.
  7. Walsh D, Davis M, Ripamonti C, Bruera E, Davies A, Molassiotis A. 2016 Updated MASCC/ESMO consensus recommendations: Management of nausea and vomiting in advanced cancer. Support Care Cancer. 2017 Jan;25(1):333-340. Epub 2016 Aug 17.
  8. Murray-Brown F, Dorman S. Haloperidol for the treatment of nausea and vomiting in palliative care patients. Cochrane Database Syst Rev. 2015 Nov 2;11:CD006271.
  9. Mucke M, Weier M, Carter C, Copeland J, Degenhardt L, Cuhls H, et al. Systematic review and meta-analysis of cannabinoids in palliative medicine. J Cachexia Sarcopenia Muscle. 2018 Apr;9(2):220-234. doi: 10.1002/jcsm.12273. Epub 2018 Feb 5.
  10. Zeng YS, Wang C, Ward KE, Hume AL. Complementary and Alternative Medicine in Hospice and Palliative Care: A Systematic Review. J Pain Symptom Manage. 2018 Nov;56(5):781-794.e4. doi: 10.1016/j.jpainsymman.2018.07.016. Epub 2018 Aug 2.

Last updated 30 October 2019