Review collection - Palliative sedation

37 reviews


Kauzner S, Heckel M, Ostgathe C, Schneider M, Bausewein C, Schildmann E, Kremling A, Ziegler K, Klein C. Documentation of Sedation in Palliative Care: A Scoping Review of Requirements, Recommendations, and Templates. J Palliat Med. 2023 May 4. doi: 10.1089/jpm.2022.0476. Epub ahead of print.

Tan F, Li N, Wu Y, Zhang C. Palliative sedation determinants: systematic review and meta-analysis in palliative medicine. BMJ Support Palliat Care. 2023 Aug 8:spcare-2022-004085. doi: 10.1136/spcare-2022-004085. Epub ahead of print.

Tomczyk M, Jaques C, Jox RJ. Palliative sedation: ethics in clinical practice guidelines - systematic review. BMJ Support Palliat Care. 2023 Aug 11:spcare-2023-004266. doi: 10.1136/spcare-2023-004266. Epub ahead of print.


Belar A, Arantzamendi M, Menten J, Payne S, Hasselaar J, Centeno C. The Decision-Making Process for Palliative Sedation for Patients with Advanced Cancer-Analysis from a Systematic Review of Prospective Studies. Cancers (Basel). 2022 Jan 8;14(2):301. doi: 10.3390/cancers14020301.

Tomczyk M, Jaques C, Jox RJ. Clinical Practice Guidelines on Palliative Sedation Around the World: A Systematic Review. J Palliat Care. 2022 Nov 28:8258597221138674. doi: 10.1177/08258597221138674. Epub ahead of print.


Arantzamendi M, Belar A, Payne S, Rijpstra M, Preston N, Menten J, Van der Elst M, Radbruch L, Hasselaar J, Centeno C. Clinical aspects of palliative sedation in prospective studies. A systematic review. J Pain Symptom Manage. 2021 Apr;61(4):831-844.e10. doi: 10.1016/j.jpainsymman.2020.09.022. Epub 2020 Sep 19.

Robijn L, Deliens L, Scherrens AL, Pauwels NS, Pype P, Rietjens J, Chambaere K. A systematic review of quality improvement initiatives for continuous sedation until death. Palliat Med. 2021 Apr;35(4):670-682. doi: 10.1177/0269216321996990. Epub 2021 Mar 15.

Senderovich H, Waicus S. Is there a role for phenobarbital in palliative care: A systematic review. Palliat Med Pract. 2021;15(2):163-171. doi: 10.5603/PMPI.2021.0011


Belar A, Arantzamendi M, Payne S, Preston N, Rijpstra M, Hasselaar J, Radbruch L, Vanderelst M, Ling J, Centeno C. How to measure the effects and potential adverse events of palliative sedation? An integrative review. Palliat Med. 2020 Dec 14:269216320974264. doi: 10.1177/0269216320974264. Epub ahead of print.

Kremling A, Schildmann J. What do you mean by "palliative sedation"? : Pre-explicative analyses as preliminary steps towards better definitions. BMC Palliat Care. 2020 Sep 23;19(1):147. doi: 10.1186/s12904-020-00635-9.

Wright DK, Gastmans C, Vandyk A, de Casterlé BD. Moral identity and palliative sedation: A systematic review of normative nursing literature. Nurs Ethics. 2020 May;27(3):868-886. doi: 10.1177/0969733019876312. Epub 2019 Oct 21.


Krooupa AM, Vivat B, McKeever S, Marcus E, Sawyer J, Stone P. Identification and evaluation of observational measures for the assessment and/or monitoring of level of consciousness in adult palliative care patients: A systematic review for I-CAN-CARE. Palliat Med. 2019 Aug 22:269216319871666. doi: 10.1177/0269216319871666. [Epub ahead of print]

Rodrigues P, Menten J, Gastmans C. Physicians' perceptions of palliative sedation for existential suffering: a systematic review. BMJ Support Palliat Care. 2019 Sep 3. pii: bmjspcare-2019-001865. doi: 10.1136/bmjspcare-2019-001865. [Epub ahead of print]


Bowers B, Ryan R, Kuhn I, Barclay S. Anticipatory prescribing of injectable medications for adults at the end of life in the community: A systematic literature review and narrative synthesis. Palliat Med. 2018 Dec 4:269216318815796. doi: 10.1177/0269216318815796. [Epub ahead of print]

Rodrigues P, Crokaert J, Gastmans C. Palliative Sedation for Existential Suffering: A Systematic Review of Argument-Based Ethics Literature. J Pain Symptom Manage. 2018 Jun;55(6):1577-1590. doi: 10.1016/j.jpainsymman.2018.01.013. Epub 2018 Jan 31.


Lam M, Lam HR, Agarwal A, Chow R, Chow S, Chow E, De Longhi C, Henry B. Clinicians' views on palliative sedation for existential suffering: A systematic review and thematic synthesis of qualitative studies. J Pain Manage. 2017;10(1):31-40. [No Abstract Available].

Ziegler S, Merker H, Schmid M, Puhan MA. The impact of the inpatient practice of continuous deep sedation until death on healthcare professionals' emotional well-being: a systematic review. BMC Palliat Care. 2017 May 8;16(1):30.


Beller EM, van Driel ML, McGregor L, Truong S, Mitchell G. Palliative pharmacological sedation for terminally ill adults. Cochrane Database Syst Rev. 2015 Jan 2;1:CD010206.

Gurschick L, Mayer DK, Hanson LC. Palliative Sedation: An Analysis of International Guidelines and Position Statements. Am J Hosp Palliat Care. 2015 Sep;32(6):660-71. doi: 10.1177/1049909114533002. Epub 2014 May 7.

Schildmann EK, Schildmann J, Kiesewetter I. Medication and Monitoring in Palliative Sedation Therapy: A Systematic Review and Quality Assessment of Published Guidelines. J Pain Symptom Manage. 2015 Apr;49(4):734-746.


Abarshi EA, Papavasiliou ES, Preston N, Brown J, Payne S; EURO IMPACT. The complexity of nurses' attitudes and practice of sedation at the end of life: a systematic literature review. J Pain Symptom Manage. 2014 May;47(5):915-925.e11. Epub 2013 Sep 24.

Schildmann E, Schildmann J. Palliative sedation therapy: a systematic literature review and critical appraisal of available guidance on indication and decision making. J Palliat Med. 2014 May;17(5):601-11.


Brinkkemper T, van Norel AM, Szadek KM, Loer SA, Zuurmond WW, Perez RS. The use of observational scales to monitor symptom control and depth of sedation in patients requiring palliative sedation: a systematic review. Palliat Med. 2013 Jan;27(1):54-67.Epub 2011 Nov 1.

Papavasiliou ES, Brearley SG, Seymour JE, Brown J, Payne SA; EURO IMPACT. From Sedation to Continuous Sedation Until Death: How Has the Conceptual Basis of Sedation in End-of-Life Care Changed Over Time? J Pain Symptom Manage. 2013 Nov;46(5):691-706.Epub 2013 Apr 6.

Papavasiliou E, Payne S, Brearley S, Brown J, Seymour J. Continuous Sedation (CS) Until Death: Mapping the Literature by Bibliometric Analysis. J Pain Symptom Manage. 2013 Jun;45(6):1073-1082.

van Deijck RH, Hasselaar JG, Verhagen SC, Vissers KC, Koopmans RT. Determinants of the administration of continuous palliative sedation: a systematic review. J Palliat Med. 2013 Dec;16(12):1624-32. Epub 2013 Nov 14.


Maltoni M, Scarpi E, Rosati M, Derni S, Fabbri L, Martini F, Amadori D, Nanni O. Palliative sedation in end-of-life care and survival: a systematic review. J Clin Oncol. 2012 Apr 20;30(12):1378-83. Epub 2012 Mar 12.


Bruce A, Boston P. Relieving existential suffering through palliative sedation: discussion of an uneasy practice. J Adv Nurs. 2011 Dec;67(12):2732-40. doi: 10.1111/j.1365-2648.2011.05711.x. Epub 2011 Jun 1.

Mercadante S, Porzio G, Valle A, Fusco F, Aielli F, Costanzo V; "Home Care Italy" Group. Palliative sedation in patients with advanced cancer followed at home: a systematic review. J Pain Symptom Manage. 2011 Apr;41(4):754-60. Epub 2011 Jan 12.


McWilliams K, Keeley PW, Waterhouse ET. Propofol for terminal sedation in palliative care: a systematic review. J Palliat Med. 2010 Jan;13(1):73-6.


Cherny NI, Radbruch L; Board of the European Association for Palliative Care. European Association for Palliative Care (EAPC) recommended framework for the use of sedation in palliative care. Palliat Med. 2009 Oct;23(7):581-93.


Claessens P, Menten J, Schotsmans P, Broeckaert B. Palliative sedation: a review of the research literature. J Pain Symptom Manage. 2008 Sep;36(3):310-33. Epub 2008 Jul 25.


de Graeff A, Dean M. Palliative sedation therapy in the last weeks of life: a literature review and recommendations for standards. J Palliat Med. 2007 Feb;10(1):67-85.

Engström J, Bruno E, Holm B, Hellzén O. Palliative sedation at end of life - a systematic literature review. Eur J Oncol Nurs. 2007 Feb;11(1):26-35. Epub 2006 Jul 14.


Beel A, McClement SE, Harlos M. Palliative sedation therapy: a review of definitions and usage. Int J Palliat Nurs. 2002 Apr;8(4):190-9.

Morita T, Tsuneto S, Shima Y. Definition of sedation for symptom relief: a systematic literature review and a proposal of operational criteria. J Pain Symptom Manage. 2002 Oct;24(4):447-53.


Cowan JD, Walsh D. Terminal sedation in palliative medicine--definition and review of the literature. Support Care Cancer. 2001 Sep;9(6):403-7.

Last updated 06 September 2023