Review collection - Delirium

73 reviews


Bryans A, Siddiqi N, Burry L, Clarke M, Koffman J, Agar MR, Rose L. A core outcome set for interventions to prevent and/or treat delirium in palliative care. J Pain Symptom Manage. 2023 Jun 12:S0885-3924(23)00521-3. doi: 10.1016/j.jpainsymman.2023.05.013. Epub ahead of print.

Matsuda Y, Tanimukai H, Inoue S, Hirayama T, Kanno Y, Kitaura Y, Inada S, Sugano K, Yoshimura M, Harashima S, Wada S, Hasegawa T, Okamoto Y, Dotani C, Takeuchi M, Kako J, Sadahiro R, Kishi Y, Uchida M, Ogawa A, Inagaki M, Okuyama T. A revision of JPOS/JASCC clinical guidelines for delirium in adult cancer patients: a summary of recommendation statements. Jpn J Clin Oncol. 2023 May 15:hyad042. doi: 10.1093/jjco/hyad042. Epub ahead of print.


Hession A, Luckett T, Chang S, Currow D, Barbato M. End-of-life dreams and visions: A systematic integrative review. Palliat Support Care. 2022 Aug 1:1-10. doi: 10.1017/S1478951522000876. Epub ahead of print.


Agar MR, Siddiqi N, Hosie A, Boland JW, Johnson MJ, Featherstone I, Lawlor PG, Bush SH, Page V, Amgarth-Duff I, Garcia M, Disalvo D, Rose L; Del-COrS Group. Outcomes and measures of delirium interventional studies in palliative care to inform a core outcome set: A systematic review. Palliat Med. 2021 Aug 27:2692163211040186. doi: 10.1177/02692163211040186. Epub ahead of print.

Featherstone I, Sheldon T, Johnson M, Woodhouse R, Boland JW, Hosie A, Lawlor P, Russell G, Bush S, Siddiqi N. Risk factors for delirium in adult patients receiving specialist palliative care: A systematic review and meta-analysis. Palliat Med. 2021 Dec 20:2692163211065278. doi: 10.1177/02692163211065278. Epub ahead of print.

Featherstone I, Hosie A, Siddiqi N, Grassau P, Bush SH, Taylor J, Sheldon T, Johnson MJ. The experience of delirium in palliative care settings for patients, family, clinicians and volunteers: A qualitative systematic review and thematic synthesis. Palliat Med. 2021 Mar 30:2692163211006313. doi: 10.1177/02692163211006313. Epub ahead of print.

Guo D, Lin T, Deng C, Zheng Y, Gao L, Yue J. Risk Factors for Delirium in the Palliative Care Population: A Systematic Review and Meta-Analysis. Front Psychiatry. 2021 Oct 21;12:772387. doi: 10.3389/fpsyt.2021.772387.

Senderovich H, Waicus S. Is there a role for phenobarbital in palliative care: A systematic review. Palliat Med Pract. 2021;15(2):163-171. doi: 10.5603/PMPI.2021.0011

Watt CL, Scott M, Webber C, Sikora L, Bush SH, Kabir M, Boland JW, Woodhouse R, Sands MB, Lawlor PG. Delirium screening tools validated in the context of palliative care: A systematic review. Palliat Med. 2021 Feb 16:269216321994730. doi: 10.1177/0269216321994730. Epub ahead of print.


Alexander SA. Intensive Care Unit Nursing Priorities in the United States. Crit Care Nurs Clin North Am. 2021 Mar;33(1):1-20. doi: 10.1016/j.cnc.2020.10.001. Epub 2020 Dec 24.

Finucane AM, Jones L, Leurent B, Sampson EL, Stone P, Tookman A, Candy B. Drug therapy for delirium in terminally ill adults. Cochrane Database Syst Rev. 2020 Jan 21;1(1):CD004770. doi: 10.1002/14651858.CD004770.pub3.

Jeong E, Park J, Lee J. Diagnostic Test Accuracy of the 4AT for Delirium Detection: A Systematic Review and Meta-Analysis. Int J Environ Res Public Health. 2020 Oct 15;17(20):E7515. doi: 10.3390/ijerph17207515.

Lawlor PG, Rutkowski NA, MacDonald AR, Ansari MT, Sikora L, Momoli F, Kanji S, Wright DK, Rosenberg E, Hosie A, Pereira JL, Meagher D, Rice J, Scott J, Bush SH. A Scoping Review to Map Empirical Evidence Regarding Key Domains and Questions in the Clinical Pathway of Delirium in Palliative Care. J Pain Symptom Manage. 2019 Mar;57(3):661-681.e12. doi: 10.1016/j.jpainsymman.2018.12.002. Epub 2018 Dec 12.

Leng M, Zhao Y, Wang Z. Comparative efficacy of non-pharmacological interventions on agitation in people with dementia: A systematic review and Bayesian network meta-analysis. Int J Nurs Stud. 2020 Feb;102:103489. doi: 10.1016/j.ijnurstu.2019.103489. Epub 2019 Nov 25.

Li Y, Ma J, Jin Y, Li N, Zheng R, Mu W, Wang J, Si JH, Chen J, Shang HC. Benzodiazepines for treatment of patients with delirium excluding those who are cared for in an intensive care unit. Cochrane Database Syst Rev. 2020 Feb 28;2(2):CD012670. doi: 10.1002/14651858.CD012670.pub2.

Smith TO, Gilbert AW, Sreekanta A, Sahota O, Griffin XL, Cross JL, Fox C, Lamb SE. Enhanced rehabilitation and care models for adults with dementia following hip fracture surgery. Cochrane Database Syst Rev. 2020 Feb 7;2(2):CD010569. doi: 10.1002/14651858.CD010569.pub3.


Hosie A, Siddiqi N, Featherstone I, Johnson M, Lawlor PG, Bush SH, Amgarth-Duff I, Edwards L, Cheah SL, Phillips J, Agar M. Inclusion, characteristics and outcomes of people requiring palliative care in studies of non-pharmacological interventions for delirium: A systematic review. Palliat Med. 2019 Jun 28:269216319853487. doi: 10.1177/0269216319853487. [Epub ahead of print]

Krooupa AM, Vivat B, McKeever S, Marcus E, Sawyer J, Stone P. Identification and evaluation of observational measures for the assessment and/or monitoring of level of consciousness in adult palliative care patients: A systematic review for I-CAN-CARE. Palliat Med. 2019 Aug 22:269216319871666. doi: 10.1177/0269216319871666. [Epub ahead of print]

Skelton L, Guo P. Evaluating the effects of the pharmacological and nonpharmacological interventions to manage delirium symptoms in palliative care patients: systematic review. Curr Opin Support Palliat Care. 2019 Sep 3. doi: 10.1097/SPC.0000000000000458. [Epub ahead of print]

Woodhouse R, Burton JK, Rana N, Pang YL, Lister JE, Siddiqi N. Interventions for preventing delirium in older people in institutional long-term care. Cochrane Database Syst Rev. 2019 Apr 23;4:CD009537. doi: 10.1002/14651858.CD009537.pub3.


Coyle MA, Chang HC, Burns P, Traynor V. Impact of Interactive Education on Health Care Practitioners and Older Adults at Risk of Delirium: A Literature Review. J Gerontol Nurs. 2018 Aug 1;44(8):41-48. doi: 10.3928/00989134-20180626-02.

Hshieh TT, Yang T, Gartaganis SL, Yue J, Inouye SK. Hospital Elder Life Program: Systematic Review and Meta-analysis of Effectiveness. Am J Geriatr Psychiatry. 2018 Oct;26(10):1015-1033. doi: 10.1016/j.jagp.2018.06.007. Epub 2018 Jun 26.

Johnson RJ 3rd. A research study review of effectiveness of treatments for psychiatric conditions common to end-stage cancer patients: needs assessment for future research and an impassioned plea. BMC Psychiatry. 2018 Apr 3;18(1):85. doi: 10.1186/s12888-018-1651-9.

Khan SS, Ye B, Taati B, Mihailidis A. Detecting agitation and aggression in people with dementia using sensors-A systematic review. Alzheimers Dement. 2018 Mar 20. pii: S1552-5260(18)30046-3. doi: 10.1016/j.jalz.2018.02.004. [Epub ahead of print]

Klingman KJ, Sullivan S. Associations between Sleep Disorders and Comfort at End-of-Life: Opportunities for Improvement. Sleep Med Res. 2018 Dec 30;9(2):110-114. doi:

Quispel-Aggenbach DWP, Holtman GA, Zwartjes HAHT, Zuidema SU, Luijendijk HJ. Attention, arousal and other rapid bedside screening instruments for delirium in older patients: a systematic review of test accuracy studies. Age Ageing. 2018 Apr 25. doi: 10.1093/ageing/afy058. [Epub ahead of print]

Warren N, O'Gorman C, Hume Z, Kisely S, Siskind D. Delusions in Parkinson's Disease: A Systematic Review of Published Cases. Neuropsychol Rev. 2018 Aug 2. doi: 10.1007/s11065-018-9379-3. [Epub ahead of print]


Bush SH, Tierney S, Lawlor PG. Clinical Assessment and Management of Delirium in the Palliative Care Setting. Drugs. 2017 Oct;77(15):1623-1643. doi: 10.1007/s40265-017-0804-3.

Finucane AM, Lugton J, Kennedy C, Spiller JA. The experiences of caregivers of patients with delirium, and their role in its management in palliative care settings: an integrative literature review. Psychooncology. 2017 Mar;26(3):291-300. Epub 2016 May 1.

Lawley H, Hewison A. An integrative literature review exploring the clinical management of delirium in patients with advanced cancer. J Clin Nurs. 2017 Dec;26(23-24):4172-4183. doi: 10.1111/jocn.13960. Epub 2017 Aug 30.


Bull MJ, Boaz L, Jermé M. Educating Family Caregivers for Older Adults About Delirium: A Systematic Review. Worldviews Evid Based Nurs. 2016 Jun;13(3):232-40. Epub 2016 Mar 10.

Forcen FE, Matsoukas K, Alici Y. Antipsychotic-induced akathisia in delirium: A systematic review. Palliat Support Care. 2016 Feb;14(1):77-84. Epub 2015 Jun 19.

Jackson TA, Wilson D, Richardson S, Lord JM. Predicting outcome in older hospital patients with delirium: a systematic literature review. Int J Geriatr Psychiatry. 2016 Apr;31(4):392-9. Epub 2015 Aug 24.


Bozzo M. The barriers and enablers related to the early recognition of delirium in older palliative care patients--An integrative literature review. Aust Nurs Midwifery J. 2015 Sep;23(3):28-31.

De J, Wand AP. Delirium Screening: A Systematic Review of Delirium Screening Tools in Hospitalized Patients. Gerontologist. 2015 Dec;55(6):1079-99. Epub 2015 Nov 5.

Serafim RB, Bozza FA, Soares M, do Brasil PE, Tura BR, Ely EW, Salluh JI. Pharmacologic prevention and treatment of delirium in intensive care patients: A systematic review. J Crit Care. 2015 Aug;30(4):799-807. Epub 2015 Apr 17.


de Jonghe A, van de Glind EM, van Munster BC, de Rooij SE. Underrepresentation of patients with pre-existing cognitive impairment in pharmaceutical trials on prophylactic or therapeutic treatments for delirium: a systematic review. J Psychosom Res. 2014 Mar;76(3):193-9.Epub 2013 Dec 31.

Sockalingam S, Tan A, Hawa R, Pollex H, Abbey S, Hodges BD. Interprofessional education for delirium care: a systematic review. J Interprof Care. 2014 Jul;28(4):345-51.


Hosie A, Davidson PM, Agar M, Sanderson CR, Phillips J. Delirium prevalence, incidence, and implications for screening in specialist palliative care inpatient settings: A systematic review. Palliat Med. 2013 Jun;27(6):486-98. Epub 2012 Sep 17.


Candy B, Jackson KC, Jones L, Leurent B, Tookman A, King M. Drug therapy for delirium in terminally ill adult patients. Cochrane Database Syst Rev. 2012 Nov 14;11:CD004770.

Morandi A, McCurley J, Vasilevskis EE, Fick DM, Bellelli G, Lee P, Jackson JC, Shenkin SD, Marcotrabucchi, Schnelle J, Inouye SK, Ely EW, MacLullich A. Tools to detect delirium superimposed on dementia: a systematic review. J Am Geriatr Soc. 2012 Nov;60(11):2005-13. Epub 2012 Oct 5.

Shi Q, Presutti R, Selchen D, Saposnik G. Delirium in acute stroke: a systematic review and meta-analysis. Stroke. 2012 Mar;43(3):645-9. Epub 2012 Jan 19.


Bélanger L, Ducharme F. Patients' and nurses' experiences of delirium: a review of qualitative studies. Nurs Crit Care. 2011 Nov-Dec;16(6):303-15.

Clegg A, Young JB. Which medications to avoid in people at risk of delirium: a systematic review. Age Ageing. 2011 Jan;40(1):23-9. Epub 2010 Nov 9.

Creten C, Van Der Zwaan S, Blankespoor RJ, Leroy PL, Schieveld JN.Pediatric delirium in the pediatric intensive care unit: a systematic review and an update on key issues and research questions. Minerva Anestesiol. 2011 Nov;77(11):1099-107. Epub 2011 May 26.

Flaherty JH, Gonzales JP, Dong B. Antipsychotics in the treatment of delirium in older hospitalized adults: a systematic review. J Am Geriatr Soc. 2011 Nov;59 Suppl 2:S269-76.

Grover S, Mattoo SK, Gupta N. Usefulness of atypical antipsychotics and choline esterase inhibitors in delirium: a review. Pharmacopsychiatry. 2011 Mar;44(2):43-54. Epub 2011 Mar 10.


Canadian Coalition for Seniors Mental Health. Guideline on the assessment and treatment of Delirium in older adults at the end of life (3.28MB pdf). Toronto: Canadian Coalition for Seniors Mental Health; 2010.

Dasgupta M, Hillier LM. Factors associated with prolonged delirium: a systematic review. Int Psychogeriatr. 2010 May;22(3):373-94. Epub 2010 Jan 21.

de Jonghe A, Korevaar JC, van Munster BC, de Rooij SE. Effectiveness of melatonin treatment on circadian rhythm disturbances in dementia. Are there implications for delirium? A systematic review. Int J Geriatr Psychiatry. 2010 Dec;25(12):1201-8. doi: 10.1002/gps.2454.

Dy SM, Apostol CC. Evidence-based approaches to other symptoms in advanced cancer. Cancer J. 2010 Sep-Oct;16(5):507-13.

Hatherill S, Flisher AJ. Delirium in children and adolescents: a systematic review of the literature. J Psychosom Res. 2010 Apr;68(4):337-44. Epub 2010 Jan 12.

Wong CL, Holroyd-Leduc J, Simel DL, Straus SE. Does this patient have delirium?: value of bedside instruments. JAMA. 2010 Aug 18;304(7):779-86.


Campbell N, Boustani MA, Ayub A, Fox GC, Munger SL, Ott C, Guzman O, Farber M, Ademuyiwa A, Singh R. Pharmacological management of delirium in hospitalized adults--a systematic evidence review. J Gen Intern Med. 2009 Jul;24(7):848-53. Epub 2009 May 8.

Cole MG, Ciampi A, Belzile E, Zhong L. Persistent delirium in older hospital patients: a systematic review of frequency and prognosis. Age Ageing. 2009 Jan;38(1):19-26. Epub 2008 Nov 18.

Lorenz KA, Dy SM, Naeim A, Walling AM, Sanati H, Smith P, Shanman R, Roth CP, Asch SM. Quality measures for supportive cancer care: the Cancer Quality-ASSIST Project. J Pain Symptom Manage. 2009 Jun;37(6):943-64. Epub 2009 Apr 8.

Peritogiannis V, Stefanou E, Lixouriotis C, Gkogkos C, Rizos DV. Atypical antipsychotics in the treatment of delirium. Psychiatry Clin Neurosci. 2009 Oct;63(5):623-31. Epub 2009 Aug 10.

Seitz DP, Gill SS. Neuroleptic malignant syndrome complicating antipsychotic treatment of delirium or agitation in medical and surgical patients: case reports and a review of the literature. Psychosomatics. 2009 Jan-Feb;50(1):8-15.


Bourne RS, Tahir TA, Borthwick M, Sampson EL. Drug treatment of delirium: past, present and future. J Psychosom Res. 2008 Sep;65(3):273-82.

Leonard M, Agar M, Mason C, Lawlor P. Delirium issues in palliative care settings. J Psychosom Res. 2008 Sep;65(3):289-98.

O'Malley G, Leonard M, Meagher D, O'Keeffe ST. The delirium experience: a review. J Psychosom Res. 2008 Sep;65(3):223-8.

Ozbolt LB, Paniagua MA, Kaiser RM. A typical antipsychotics for the treatment of delirious elders. J Am Med Dir Assoc. 2008 Jan;9(1):18-28.

Steis MR, Fick DM. Are nurses recognizing delirium? A systematic review. J Gerontol Nurs. 2008 Sep;34(9):40-8.


Keeley P. Delirium at the end of life. Clin Evid (Online). 2007 Jun 1;2007. pii: 2405.

Lonergan E, Britton AM, Luxenberg J, Wyller T. Antipsychotics for delirium. Cochrane Database Syst Rev. 2007 Apr 18;(2):CD005594.

Seitz DP, Gill SS, van Zyl LT. Antipsychotics in the treatment of delirium: a systematic review. J Clin Psychiatry. 2007 Jan;68(1):11-21.

Siddiqi N, Stockdale R, Britton AM, Holmes J. Interventions for preventing delirium in hospitalised patients. Cochrane Database Syst Rev. 2007 Apr 18;(2):CD005563.


Boyle DA. Delirium in older adults with cancer: implications for practice and research. Oncol Nurs Forum. 2006 Jan 1;33(1):61-78.


de Rooij SE, Schuurmans MJ, van der Mast RC, Levi M. Clinical subtypes of delirium and their relevance for daily clinical practice: a systematic review. Int J Geriatr Psychiatry. 2005 Jul;20(7):609-15.

Gaudreau JD, Gagnon P, Roy MA, Harel F, Tremblay A. Association between psychoactive medications and delirium in hospitalized patients: a critical review. Psychosomatics. 2005 Jul-Aug;46(4):302-16.


Jackson K, Lipman A. Drug therapy for delirium in terminally ill adult patients. Cochrane Database Syst Rev. 2004;(2):CD004770 [Updated 2012].

Kehl KA. Treatment of terminal restlessness: a review of the evidence. J Pain Palliat Care Pharmacother. 2004;18(1):5-30.


Fick DM, Agostini JV, Inouye SK. Delirium superimposed on dementia: a systematic review. J Am Geriatr Soc. 2002 Oct;50(10):1723-32.

Last updated 18 July 2023