Review collection - Constipation and defecation

24 reviews


Ying J, Xiao R, Xu L, Yan M. Transcutaneous Electrical Nerve Stimulation (TENS) for Opioid-Induced Constipation in Palliative Care: A Systematic Review and Network Meta-Analysis. Evid Based Complement Alternat Med. 2023 Apr 19;2023:5383821. doi: 10.1155/2023/5383821.


Davies A, Leach C, Caponero R, Dickman A, Fuchs D, Paice J, Emmanuel A. MASCC recommendations on the management of constipation in patients with advanced cancer. Support Care Cancer. 2019 Aug 9. doi: 10.1007/s00520-019-05016-4. [Epub ahead of print]

Santos RP, Fava SMCL, Dázio EMR. Self-care of elderly people with ostomy by colorectal cancer. J Coloproctol (Rio J). 2019.


Alsalimy N, Madi L, Awaisu A. Efficacy and safety of laxatives for chronic constipation in long-term care settings: A systematic review. J Clin Pharm Ther. 2018 Jun 9. doi: 10.1111/jcpt.12721. [Epub ahead of print]

Candy B, Jones L, Vickerstaff V, Larkin PJ, Stone P. Mu-opioid antagonists for opioid-induced bowel dysfunction in people with cancer and people receiving palliative care. Cochrane Database Syst Rev. 2018 Jun 5;6:CD006332. doi: 10.1002/14651858.CD006332.pub3. [Epub ahead of print]

Muldrew DH, Hasson F, Carduff E, Clarke M, Coast J, Finucane A, Graham L, Larkin P, McCorry NK, Slater P, Watson M, Wright E, McIlfatrick S. Assessment and management of constipation for patients receiving palliative care in specialist palliative care settings: A systematic review of the literature. Palliat Med. 2018 May;32(5):930-938. doi: 10.1177/0269216317752515. Epub 2018 Feb 12.

Sowerbutts AM, Lal S, Sremanakova J, Clamp A, Todd C, Jayson GC, Teubner A, Raftery AM, Sutton EJ, Hardy L, Burden S. Home parenteral nutrition for patients with inoperable malignant bowel obstruction. Cochrane Database Syst Rev. 2018 Aug 10;8:CD012812. doi: 10.1002/14651858.CD012812.pub2. [Epub ahead of print]

Wardill HR, Van Sebille YZA, Ciorba MA, Bowen JM. Prophylactic probiotics for cancer therapy-induced diarrhoea: a meta-analysis. Curr Opin Support Palliat Care. 2018 Jun;12(2):187-197. doi: 10.1097/SPC.0000000000000338.


Ní Laoire Á, Fettes L, Murtagh FE. A systematic review of the effectiveness of palliative interventions to treat rectal tenesmus in cancer. Palliat Med. 2017 Dec;31(10):975-981. doi: 10.1177/0269216317697897. Epub 2017 Mar 1.


Candy B, Jones L, Larkin PJ, Vickerstaff V, Tookman A, Stone P. Laxatives for the management of constipation in people receiving palliative care. Cochrane Database Syst Rev. 2015 May 13;5:CD003448. [Update of Candy, et al; 2011]

Gaertner J, Siemens W, Camilleri M, Davies A, Drossman DA, Webster LR, Becker G. Definitions and outcome measures of clinical trials regarding opioid-induced constipation: a systematic review. J Clin Gastroenterol. 2015 Jan;49(1):9-16.

Siemens W, Gaertner J, Becker G. Advances in pharmacotherapy for opioid-induced constipation - a systematic review. Expert Opin Pharmacother. 2015 Mar;16(4):515-32.Epub 2014 Dec 24.


Gatti A, Sabato AF Management of opioid-induced constipation in cancer patients: focus on methylnaltrexone. Clin Drug Investig. 2012 May 1;32(5):293-301.


Candy B, Jones L, Goodman ML, Drake R, Tookman A. Laxatives or methylnaltrexone for the management of constipation in palliative care patients. Cochrane Database Syst Rev. 2011 Jan 19;(1):CD003448.


Ahmedzai SH, Boland J. Constipation in people prescribed opioids. Clin Evid (Online). 2010;04:2407. (Updated)


Larkin PJ, Sykes NP, Centeno C, Ellershaw JE, Elsner F, Eugene B, Gootjes JR, Nabal M, Noguera A, Ripamonti C, Zucco F, Zuurmond WW; European Consensus Group on Constipation in Palliative Care. The management of constipation in palliative care: clinical practice recommendations. Palliat Med. 2008 Oct;22(7):796-807.

Phillips RS, Gibson F. A systematic review of treatments for constipation in children and young adults undergoing cancer treatment. J Pediatr Hematol Oncol. 2008 Nov;30(11):829-30.

Woolery M, Bisanz A, Lyons HF, Gaido L, Yenulevich M, Fulton S, McMillan SC. Putting evidence into practice: Evidence based interventions for the prevention and management of constipation in patients with cancer. Clin J Oncol Nurs. 2008 Apr;12(2):317-37.


Becker G, Galandi D, Blum HE. Peripherally acting opioid antagonists in the treatment of opiate-related constipation: a systematic review. J Pain Symptom Manage. 2007 Nov;34(5):547-65. Epub 2007 Sep 27.

Mendoza J, Legido J, Rubio S, Gisbert JP. Systematic review: the adverse effects of sodium phosphate enema. Aliment Pharmacol Ther. 2007 Jul 1;26(1):9-20.

Yuan CS. Methylnaltrexone mechanisms of action and effects on opioid bowel dysfunction and other opioid adverse effects. Ann Pharmacother. 2007 Jun;41(6):984-93. Epub 2007 May 15.


Jones MP, Talley NJ, Nuyts G, Dubois D. Lack of objective evidence of efficacy of laxatives in chronic constipation. Dig Dis Sci. 2002 Oct;47(10):2222-30.


Hurdon V, Viola R, Schroder C. How useful is docusate in patients at risk for constipation? a systematic review of the evidence in the chronically ill. J Pain Symptom Manage. 2000 Feb;19(2):130-6.


Kot TV, Pettit-Young NA. Lactulose in the management of constipation: a current review. Ann Pharmacother. 1992 Oct;26(10):1277-82.

Last updated 06 June 2023